Circulation

Peripheral Artery Disease: Complete Guide

PAD causes narrowed leg arteries, reducing blood flow. It's a marker of widespread cardiovascular disease and, if untreated, can progress to critical limb ischaemia.

Main symptom
Intermittent claudication (leg pain on walking)
Key test
Ankle-brachial index (ABI)
Strongly associated with
Smoking, diabetes
Severe form
Critical limb ischaemia

Symptoms by Severity

StageSymptoms
AsymptomaticNo symptoms, found incidentally or on screening
Intermittent claudicationLeg pain/cramping on walking, relieved by rest — classic symptom
Rest painPain even at rest, especially at night — more severe disease
Critical limb ischaemiaNon-healing ulcers, gangrene — limb-threatening emergency

The Ankle-Brachial Index (ABI) Test

ABI ValueInterpretation
1.0-1.4Normal
0.9-1.0Borderline
0.4-0.9Mild-moderate PAD
<0.4Severe PAD
>1.4May indicate calcified, non-compressible vessels (common in diabetes) — further testing needed

Treatment Approach

Critical Limb Ischaemia — EmergencySudden severe leg pain, pale/cold leg, or non-healing ulcers with reduced pulses require urgent vascular assessment, as this can progress to gangrene and limb loss without prompt treatment.
PAD Is a Marker of Whole-Body Vascular DiseaseHaving PAD significantly increases the risk of heart attack and stroke, as it reflects widespread atherosclerosis. Aggressive management of cardiovascular risk factors is essential, not just leg symptom control.
Is leg pain when walking always PAD?
No — spinal stenosis can cause similar walking-related leg pain (neurogenic claudication), but typically improves with leaning forward or sitting rather than just standing still, unlike vascular claudication.
Can PAD be reversed?
Established atherosclerotic narrowing doesn't reverse, but disease progression can be significantly slowed, and symptoms improved, with smoking cessation, exercise, and medical treatment.
Medical Disclaimer: This page is for general education only and does not replace professional medical advice. Always consult a qualified healthcare provider.