Why Sertraline Is Often First Choice
- Relatively few drug interactions compared to some other SSRIs
- Good safety data in pregnancy and breastfeeding
- Effective across a broad range of conditions (depression, generalised anxiety, panic disorder, OCD, PTSD, social anxiety)
- Generally well-tolerated side effect profile
Starting Dose and Titration
| Week | Typical Dose |
|---|---|
| Week 1-2 | 50mg daily |
| Week 3-4 | Increase to 100mg if needed |
| Ongoing | Up to 200mg daily maximum, based on response |
Common Side Effects
- Nausea (usually improves after 1-2 weeks)
- Diarrhoea — more common with sertraline than some other SSRIs
- Insomnia or vivid dreams
- Sexual side effects
- Initial increase in anxiety before improvement
Take With FoodTaking sertraline with food can reduce the nausea and stomach upset commonly experienced when starting treatment.
Is sertraline safe in pregnancy?
Sertraline is generally considered one of the safer SSRI options in pregnancy based on available safety data, though the decision to continue or start treatment in pregnancy should always weigh individual risks and benefits with your doctor.
How long will I need to take sertraline?
Typically at least 6 months after feeling well for a first episode of depression; longer-term treatment is often recommended for recurrent depression or anxiety disorders.
Medical Disclaimer: This page is for general education only and does not replace professional medical advice. Always consult a qualified healthcare provider.